KalVista Pharmaceuticals, Inc. announces the publication of new sebetralstat data in both the Journal of Medicinal Chemistry and Xenobiotica. The Journal of Medicinal Chemistry article focuses on the medicinal chemistry KalVista conducted that led to the discovery of sebetralstat, with properties optimized for the on-demand treatment of HAE. Data with sebetralstat showed high selectivity against related human serine proteases. This feature, together with the rapid and high plasma exposure and near-complete inhibition of plasma kallikrein (PKa) in preclinical studies, supported its progression into toxicology and ultimately clinical assessment. Sebetralstat has since advanced to phase 3 trials. In Xenobiotica, sebetralstat was shown to be rapidly absorbed into the systemic circulation (median Tmax of 0.5 hours) and demonstrated absorption, metabolism, and excretion properties that would be beneficial for on-demand treatment of HAE attacks.
“These foundational papers further demonstrate the promise of sebetralstat for the on-demand treatment of HAE attacks,” says Andrew Crockett, CEO of KalVista. “We are excited to continue the development of sebetralstat in our phase 3 KONFIDENT trial and look forward to delivering an oral option for on-demand treatment for people living with HAE.”
(Source: KalVista)
