KalVista Pharmaceuticals, Inc. announces data from the Phase 1 clinical trials of oral, on-demand treatment KVD900 in patients with HAE, published online by the Journal of Allergy and Clinical Immunology (JACI).

The objective of the Phase 1 studies was to evaluate the safety, tolerability, pharmacokinetics, and clinical pharmacology of KVD900, an orally administered inhibitor of plasma kallikrein in healthy adults. KVD900 was administered to 98 participants in total, and the data showed that KVD900 achieves near-complete plasma kallikrein inhibition within 30 minutes and was generally safe and well tolerated.

“We are pleased to see these data published in JACI to further describe our ongoing work to bring a safe, oral on-demand treatment option to the market for HAE patients,” says Andrew Crockett, CEO of KalVista. “These data show that KVD900 rapidly suppresses plasma kallikrein activity, a key mediator of HAE attacks, and may provide the early relief from HAE attack progression that represents a currently unmet need in orally administered management of the disease. These findings have since been further validated by the results of our Phase 2 clinical trial for KVD900.”

Additional details can be found in the manuscript, which is available in the “Articles in Press” section of the JACI website.(Source: KalVista)