Clinical Trials
According to clinicaltrials.gov under the U.S. National Institutes of Health, the EU Clinical Trials Register, and the International Clinical Trials Registry Platform under World Health Organization (WHO) the following trials should be recruiting at this moment (updated December 2021):
A Gene Therapy Study of BMN 331 in Subjects with HAE
– recruiting in the United States
A Study in Teenagers and Adults with HAE Type I or Type II who Use Lanadelumab as Long-Term Prophylaxis
– recruiting in Austria, France, Germany, Greece
A Study of Lanadelumab in Teenagers and Adults to Prevent Acute Attacks of Non-histaminergic Angioedema with Normal C1-Inhibitor (C1-INH)
– recruiting in Canada, Germany, Hungary, Italy, the Netherlands, Poland, Spain, the United States
A Study of Lanadelumab in Teenagers and Adults with HAE in Argentina
– recruiting in Argentina
A Study of Long-Term Safety and Efficacy of Lanadelumab for Prevention of Acute Attacks of Non-histaminergic Angioedema with Normal C1- Inhibitor
– recruiting in the United States
A Trial to Evaluate the Efficacy and Safety of Different Doses of KVD824 for Prophylactic Treatment of HAE Type I or II
– recruiting in Australia, Canada, Czech Republic, Germany, Hungary, New Zealand, Puerto Rico, the United Kingdom, the United States
Assessment of the State of Health, Quality of Life and Expectations of Patients with HAE
– recruiting in France
Biomarker for HAE Disease
– recruiting in Armenia, Georgia, India, Peru, Poland, Romania, Turkey
C1 Inhibitor Registry in the Treatment of HAE Attacks
– recruiting in Bulgaria, Croatia, Czech Republic, France, Germany, Hungary, Italy, North Macedonia, Norway, Poland, Slovakia, Slovenia, Sweden
Dose-ranging Study of Oral PHA-022121 for Acute Treatment of Angioedema Attacks in Patients with HAE
– recruiting in Bulgaria, Canada, Czech Republic, France, Germany, Hungary, Israel, Italy, the Netherlands, Poland, Spain, the United Kingdom, the United States
Dose-ranging Study of Oral PHA-022121 for Prophylaxis Against Angioedema Attacks in Patients with HAE Type I or Type II
– recruiting in the United States
Efficacy and Safety of Lanadelumab (SHP643) in Japanese Subjects with HAE
– recruiting in Japan
Epidemiological Analysis for HAE Disease
– recruiting in Germany, Italy, Japan, Poland, Turkey, the United Kingdom
Expanded Access Program with Lanadelumab for Japanese People with HAE
– recruiting in Japan
Firazyr General Drug Use-Results Survey (Japan)
– recruiting in Japan
Firazyr Patient Registry (Icatibant Outcome Survey – IOS)
– recruiting in Australia, Austria, Brazil, Czech Republic, Denmark, France, Germany, Greece, Ireland, Israel, Italy, Spain, Sweden, the United Kingdom
Global Registry to Gather Data on Natural History of Patients with HAE Type I and II
– recruiting in Italy
HAE Kininogen Assay
– recruiting in Germany
Involvement of Monocytic B1 and B2 Receptors in Inflammation and Chronic Vascular Disease in Patients with Hereditary Bradykinetic Angioedema
– recruiting in France
Long-term Safety and Efficacy of CSL312 (Garadacimab) in the Prophylactic Treatment of HAE Attacks
– recruiting in Australia, Canada, Czech Republic, Germany, Hong Kong, Hungary, Israel, Japan, the Netherlands, New Zealand, Russia, Spain, the United States
NTLA-2002 in Adults with HAE
– recruiting in New Zealand
Pathophysiological study for autoimmune dysregulation of HAE
– recruiting in Japan
Patient Registry to Evaluate the Real-world Safety of Ruconest
– recruiting in the United States
Study to Assess the Tolerability and Safety of Ecallantide in Children and Adolescents with HAE
– recruiting in the United States
Study to Evaluate the Real-world Effectiveness of Lanadelumab in Participants with HAE
– recruiting in Canada, Puerto Rico, the United States
Study to Evaluate the Real-World Long-Term Effectiveness of Lanadelumab in Participants with Hereditary Angioedema HAE
– recruiting in Austria, Germany, Israel, Switzerland, the United Kingdom
The influence of stress and lifestyle in HAE
– recruiting in New Zealand
The Role of the Coagulation Pathways in Recurrent Angioedema
– recruiting in France
A Study of the Burden of Illness and Treatment Patterns in Teenagers and Adults with HAE
– will be recruiting
A Study with Lanadelumab in Persons with HAE in Poland
– will be recruiting in Poland
Efficacy and Safety of GNR-038 vs Berinert in Patients with HAE
– will be recruiting in Russia
OASIS-HAE: A Study to Evaluate the Safety and Efficacy of Donidalorsen (ISIS 721744 or IONIS-PKK- LRx) in Participants with HAE
– will be recruiting
Open-label Berotralstat Access to HAE Patients Previously Enrolled in Berotralstat Studies
– will be recruiting
Read more about these and other clinical trials at
www.clinicaltrials.gov
www.clinicaltrialsregister.eu
www.apps.who.int/trialsearch
HAE related topics that might interest you
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