Exact figures regarding the frequency that HAE occurs (incidence) are not available. It is estimated that about 1 in 10,000 to 1 in 50,000 people are affected worldwide.

Exact figures regarding the frequency that HAE occurs (incidence) are not available. It is estimated that about 1 in 10,000 to 1 in 50,000 people are affected worldwide. [Agostoni 2004][ [Bowen 2008]

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Agostoni 2004: Agostoni A, Aygören-Pürsün E, Binkley KE et al. Hereditary and acquired angioedema: problems and progress: proceedings of the third C1 esterase inhibitor deficiency workshop and beyond. J Allergy Clin Immunol. 2004 Sep;114(3 Suppl):S51-131. doi: 10.1016/j.jaci.2004.06.047. PMID: 15356535; PMCID: PMC7119155.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7119155/ [Free full text]

Bowen 2008: Bowen T, Cicardi M, Bork K, et al. Hereditary angiodema: a current state-of-the-art review, VII: Canadian Hungarian 2007 International Consensus Algorithm for the Diagnosis, Therapy, and Management of Hereditary Angioedema. Ann Allergy Asthma Immunol. 2008 Jan;100(1 Suppl 2):S30-40. doi: 10.1016/s1081-1206(10)60584-4. PMID: 18220150.
https://pubmed.ncbi.nlm.nih.gov/18220150/ [Abstract]