Pharvaris GmbH announces data from a late-breaking poster planned for presentation at the recently canceled annual meeting of the American Academy of Allergy, Asthma & Immunology (AAAAI).
Pharvaris establishes a proof-of-concept model for HAE in non-human primates. In this model, PHA121 inhibited bradykinin-induced changes in blood pressure at all doses tested (0.1, 0.3, 1, 3, and 10 mg/kg given orally) with a faster onset of action than icatibant. The duration of the effect was dose-dependent.
“These results provide confidence in PHA121’s clinical profile for the treatment of HAE,” says Berndt Modig, CEO and co-founder of Pharvaris. “Combined with preliminary findings from our ongoing Phase 1 study, these data demonstrate that PHA121 is a potent, orally available bradykinin B2 receptor antagonist.”
The objective of the study was to investigate the ability of PHA121 to attenuate blood-pressure changes induced by bradykinin injection. Freely moving monkeys were challenged with bradykinin, resulting in a transient drop in blood pressure. Bradykinin is an endogenous peptide known to mediate signs and symptoms of HAE. The model was validated utilizing icatibant, a marketed injectable B2 receptor antagonist, providing back-translation from human clinical experience with icatibant.
(Source: Pharvaris)
